Delusion, one of the three kilesas, is in some ways the fundamental cause of our suffering -- because we don't see clearly the way things truly are. Our experience of ourselves and the world is distorted by our conditioned views and perceptions.
"Unentangled knowing" is an approach to meditation in which we are aware of things coming and going at the sense doors without becoming caught in them. Supported by tranquility and insight, we can rest in the knowing while being fully awake to life.
Each of us is an open-ended process, matrixed with everything else. The very open-endedness of our nature allows for transformation in the direction of happiness, once we understand the lawfulness of things and act on that understanding. The fact that we are matrixed with other beinigs/things means our individual development has positive effects on others, beyond what we can directly observe/know.