We begin with a review of how the Buddha saw "ignorance" of the basic nature of things (not so much of facts or information) as the basic problem of human life; we are as if asleep, caught in dream-like living, and need to "wake up." For the Buddha, we are especially ignorant about impermanence, dukkha (or reactivity--grabbing at the pleasant and pushing away the unpleasant or painful and believing that this is the way to happiness), the nature of the self, and nirvana or awakening. We bring in a brief report of the experience of attending the previous week's EcoDharma retreat at Spirit Rock, emphasizing especially the pervasiveness of a sense of separation--from the earth, other living beings, and each other--and the connection of such sense of separation with our systemic problems. Indigenous teachers at the retreat particularly emphasized living without such separation. The second part of the talk, we focus on the teaching of not-self (anatta), and ways of practicing that deepens our understanding of not-self, as well as how we hold this understanding of pervasive human ignorance with compassion and kindness, including in our responses to the manifestations of ignorance. The talk is followed by discussion.