The mental Factor of Vedana (pleasure, pain and neutrality) arises in every moment. Through the practice of Mindfulness we can separate our deep sense of contentment no matter the pleasure or pain aspect of experience.
First get to know them, really stay with them and nourish their arising; in particular sustain mindfulness and sink deeply into into experience, in a gentle steady to sustainable way.
The hindrances arise naturally within our practice. Developing mindfulness while the hindrances are present both brings in wisdom and transforms the underlying conditions.